Research progress on the mechanisms of neuropathic pain induced by albumin-bound paclitaxel-induced
- VernacularTitle:白蛋白结合型紫杉醇诱导神经病理性疼痛发生机制的研究进展
- Author:
Xinjun PENG
1
;
Yingjia ZHOU
Author Information
- Keywords: albumin-bound paclitaxel; neuropathic pain; microglia; astrocytes; high mobility group box 1/toll-like receptor 4 signaling pathway; Caveolin-1/toll-like receptor 4 signaling pathway; chemotherapy; tumor
- From: Journal of Clinical Medicine in Practice 2025;29(8):138-142
- CountryChina
- Language:Chinese
- Abstract: Albumin-bound paclitaxel(nab-PTX)is an important chemotherapeutic agent in the field of cancer treatment.However,its clinical application is accompanied by the occurrence of neu-ropathic pain.The mechanism by which nab-PTX induces neuropathic pain has not been fully eluci-dated.In recent years,studies have found that nab-PTX participates in neuroimmune responses by regulating microglia,astrocytes,the high mobility group box 1/toll-like receptor 4(HMGB1/TLR4)signaling pathway and the Caveolin-1/toll-like receptor 4(Caveolin-1/TLR4)signaling pathway,leading to neuropathic pain.This article reviewed the mechanisms underlying nab-PTX-induced neu-ropathic pain,with the aim of providing new insights for the diagnosis and treatment of chemotherapy-induced neuropathic pain in patients.
