A review of long non-coding RNA regulating aerobic glycolysis metabolism-epigenetic synergistic axis driving malignant progression of glioma
- VernacularTitle:长链非编码RNA通过调控有氧糖酵解代谢-表观遗传协同轴驱动胶质瘤恶性发展的研究进展
- Author:
Xinrui LAN
1
;
Ziqi LIU
;
Ruoxun WANG
;
Li QIAN
Author Information
- Keywords: long non-coding RNA; glioblastoma; aerobic glycolysis; metabolism-epigenetic interaction; glycolytic metabolism reprogramming; biomarker; therapeutic resistance; new paradigm of combined therapy
- From: Journal of Clinical Medicine in Practice 2025;29(8):132-137
- CountryChina
- Language:Chinese
- Abstract: Glioma is the most common primary tumor of the central nervous system,with glio-blastoma multiforme of World Health Organization grade Ⅳ exhibiting the highest malignancy and worst prognosis.Long non-coding RNA(lncRNA)is a type of regulatory RNA without protein-coding ability,which can promote the malignant phenotypic evolution of glioma cells and induce therapeutic resistance by reprogramming glycolytic metabolism,playing a crucial role in the malignant progression and prognosis of glioma.This paper mainly introduced the role of lncRNA in regulating the biological behavior of glioma cells and aerobic glycolysis,and proposed a new paradigm of combined therapy based on the aerobic glycolysis metabolism-epigenetic network,providing new ideas for the discovery of diagnostic biomarkers and the development of novel therapeutic strategies for glioma.
