The dual regulatory roles of N6-methyladenosine methylation in microglial polarization and neuroinflammation in ischemic stroke
- VernacularTitle:N6-甲基腺苷甲基化在缺血性脑卒中小胶质细胞极化与神经炎症中的双重调控作用研究进展
- Author:
Zhixiang XIAO
1
;
Faqing LONG
Author Information
- Keywords: ischemic stroke; microglial polarization; N6-methyladenosine methylation; neu-roinflammation; therapeutic target; M1/M2 polarization state; pro-inflammatory factor; anti-inflam-matory factor
- From: Journal of Clinical Medicine in Practice 2025;29(8):127-131
- CountryChina
- Language:Chinese
- Abstract: N6-methyladenosine(m6A)methyltransferases encompass"Writers""Erasers"and"Readers"proteins,which influence the immune response and neurorepair process in stroke by mod-ulating the M1/M2 polarization state of microglia,cytokine secretion,and neurorepair factor expres-sion.m6A methylation exacerbates inflammatory responses in the acute phase by promoting pro-in-flammatory factor expression and M1 polarization,while in the recovery phase,it facilitates tissue re-pair and neuroregeneration by increasing anti-inflammatory factor expression and M2 polarization.This paper reviewed the molecular mechanisms of m6A methylation-related enzymes and their bidirec-tional roles in the functional regulation of microglia,and evaluated the feasibility of m6A methylation as a potential therapeutic target for stroke,aiming to provide new research perspectives and therapeu-tic strategies for immune regulation and neurorepair in ischemic stroke.
