Advances in role of gut-liver axis in non-alcoholic fatty liver disease
- VernacularTitle:肠-肝轴在非酒精性脂肪性肝病中的作用研究进展
- Author:
Mingxia DING
1
;
Yawen LUO
;
Yihuai HE
Author Information
- Keywords: non-alcoholic fatty liver disease; gut; liver; gut-liver axis; gut microbiota; metab-olites; immune response; microbiota transplantation
- From: Journal of Clinical Medicine in Practice 2025;29(7):143-148
- CountryChina
- Language:Chinese
- Abstract: The gut-liver axis is critical pathway of interaction between the intestine and the liver,involving gut microbiota,intestinal permeability and immune responses.Dysbiosis of the gut microbio-ta and increased intestinal permeability lead to the translocation of bacteria and their metabolites into the systemic circulation,thereby triggering hepatic inflammation and promoting the progression of non-alcoholic fatty liver disease(NAFLD).Research on the gut-liver axis contributes to the development of novel therapeutic approaches,including fecal microbiota transplantation,antibiotic therapy and nu-tritional intervention,providing new insights for the treatment of NAFLD.This article reviewed the composition and regulatory mechanism of entero-hepatic axis,its relationship with NAFLD,and the role of drug therapy and lifestyle intervention.
