Effects of Yiyi Ren aqueous preparation on blood lipid regulation and spleen-strengthening and dampness-eliminating effects in hyperlipidemia rats with syndrome of spleen deficiency and excessive dampness
10.7619/jcmp.20250389
- VernacularTitle:薏米水制剂对高脂血症脾虚湿盛证模型大鼠血脂调控及健脾利湿效果的影响
- Author:
Qinghuan SHI
1
;
Qingqian YU
;
Zehan ZHANG
;
Bijuan LAN
;
Ruting LI
;
Fengzhi WU
;
Yongzhu WEN
;
Peng ZENG
;
Feng LI
Author Information
1. 北京中医药大学中医学院,北京,102488
- Keywords:
Yiyi Ren preparation;
hyperlipidemia;
syndrome of spleen deficiency and exces-sive dampness;
animal experiment;
blood lipid indicators;
vasoactive intestinal peptide;
antidiuretic hormone;
aldosterone
- From:
Journal of Clinical Medicine in Practice
2025;29(7):82-86,91
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of different doses of Yiyi Ren aqueous prepara-tion on blood lipid regulation and spleen-strengthening and dampness-eliminating effects in hyperlipi-demia rats with syndrome of spleen deficiency and excessive dampness.Methods Sixty SD male rats were randomly divided into blank control group,model group,low-dose,medium-dose,high-dose Yiyi Ren aqueous preparation groups,and positive drug control group,with 10 rats in each group.A hyperlipidemia rat model with syndrome of spleen deficiency and excessive dampness was estab-lished by feeding with a high-fat diet for 21 consecutive days combined with a damp bedding environment.After drug administration,behavioral tests such as grip strength,weighted swimming test,and open field test were conducted;changes in body weight in each group were observed;serum levels of total cholesterol(TC),triglycerides(TG),high-density lipoprotein cholesterol(HDL-C),and low-den-sity lipoprotein cholesterol(LDL-C)were detected;levels of vasoactive intestinal peptide(VIP),an-tidiuretic hormone(ADH),and aldosterone(ALD)were measured by enzyme-linked immunosorbent assay(ELISA).Results Compared with the blank control group,the model group showed decreased HDL-C,grip strength,exhaustive swimming time,and total distance,as well as increased TC,TG,LDL-C,ADH,ALD,and VIP(P＜0.05).Compared with the model group,TC,TG,and LDL-C levels were decreased in the medium-dose,high-dose Yiyi Ren aqueous preparation groups,and the positive drug control group,while the HDL-C levels were increased in the low-dose,medium-dose,and high-dose Yiyi Ren aqueous preparation groups and the positive drug control group(P＜0.05).Compared with the model group,the high-dose Yiyi Ren aqueous preparation group showed in-creased grip strength,exhaustive swimming time and total distance and decreased serum ADH levels(P＜0.05).Compared with the model group,the medium and high-dose Yiyi Ren aqueous prepa-ration groups showed decreased serum ALD and VIP levels(P＜0.05).Conclusion Yiyi Ren aqueous preparation has an effect on regulating blood lipid levels in hyperlipidemia rats with syn-drome of spleen deficiency and excessive dampness,and it can alleviate physical fatigue,improve abnormal exploratory behavior,and maintain normal water metabolism and motor function in rats.
