Research progress of trichorhinophalangeal syndrome type 1 in breast cancer
- VernacularTitle:毛发鼻指(趾)综合征-1基因在乳腺癌中的研究进展
- Author:
Jingchun XU
1
;
Guihong DAI
;
Lu WANG
;
Xiaowei ZHU
;
Hong YU
Author Information
- Keywords: trichorhinophalangeal syndrome type 1; globin transcription factor-1; breast canc-er; epithelial-mesenchymal transition; triple-negative breast cancer; chemoresistance; immunohisto-chemical markers; new therapeutic target
- From: Journal of Clinical Medicine in Practice 2025;29(6):143-148
- CountryChina
- Language:Chinese
- Abstract: Breast cancer is one of the most common tumors worldwide.Despite significant pro-gress in diagnosis and treatment,the incidence and mortality rates remain high due to its highly inva-sive and metastatic characteristics.Trichorhinophalangeal syndrome type 1(TRPS1)is an atypical globin transcription factor-1(GATA).It plays an important role in regulating cell proliferation and differentiation and tissue growth.Studies have found that TRPS1 is significantly overexpressed in breast cancer and closely related to tumor invasion and metastasis.TRPS1 is specifically expressed in the ductal epithelial cells of breast tissue and closely associated with the differentiation of breast ducts.In recent years,scholars have mainly focused on the role and mechanisms of TRPS1 in the di-agnosis and treatment of breast cancer.This review summarized the research progress of TRPS1 in breast cancer,aiming to further analyze its clinical application value in the occurrence,development,diagnosis,and treatment of breast cancer.
