Occurrence and risk factors of vascular calcification in 110 maintenance hemodialysis patients
- VernacularTitle:110例维持性血液透析患者血管钙化的发生情况及影响因素分析
- Author:
Guanglu ZHANG
1
;
Yanan WANG
;
Xia JIAO
Author Information
- Keywords: maintenance hemodialysis; chronic renal failure; vascular calcification; influen-cing factors; combined diagnosis; intact parathyroid hormone; sclerostin; fibroblast growth factor 23
- From: Journal of Clinical Medicine in Practice 2025;29(6):106-110
- CountryChina
- Language:Chinese
- Abstract: Objective To observe the incidence of vascular calcification in patients with chronic renal failure(CRF)undergoing maintenance hemodialysis and analyze the related influencing factors.Methods A total of 110 CRF patients undergoing maintenance hemodialysis at Xingtai Central Hos-pital in Hebei Province were selected.Vascular calcification was determined through hip,abdominal,and bilateral hand X-ray examinations,and patients were divided into calcification group(n=59,with mild,moderate,and severe calcification)and non-calcification group(n=51,without calcifica-tion)based on the calcification results.General information and laboratory indicators[white blood cell(WBC)count,hemoglobin(Hb),total cholesterol(TC),triglycerides(TG),high-density lip-oprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C),albumin(LB),serum potassium(K),serum calcium(Ca),serum phosphorus(P),serum creatinine(SCr),urea nitro-gen(BUN),uric acid(UA),intact parathyroid hormone(iPTH),high-sensitivity C-reactive pro-tein(hs-CRP),interleukin-13(IL-13),fibroblast growth factor 23(FGF23),sclerostin(SOST)]were compared between the two groups,and Logistic regression analysis was performed to screen in-fluencing factors of vascular calcification.Results There were no statistically significant differences in gender,body mass index,smoking history,and primary renal diseases between the calcification and non-calcification groups(P＞0.05).The mean age and dialysis duration were higher in the calcification group compared to the non-calcification group(P＜0.05).There were no statistically significant differences in WBC,Hb,TC,TG,HDL-C,LDL-C,K,Ca,and BUN levels between the two groups(P＞0.05).Compared with the non-calcification group,the calcification group had lower ALB and UA levels and higher P,SCr,iPTH,hs-CRP,IL-13,FGF23,and SOST levels(P＜0.05).Multivariate Logistic regression analysis showed that age,dialysis duration,and levels of P,iPTH,IL-13,FGF23,and SOST were influencing factors for vascular calcification in patients(P＜0.05).The receiver operating characteristic curve indicated that IL-13,FGF23,and SOST had cer-tain diagnostic value for vascular calcification in patients[area under the curve(AUC)＞0.7],and the diagnostic efficacy of combined IL-13,FGF23,and SOST was higher than that of each indi-cator alone(AUC=0.911,P＜0.05).Conclusion Vascular calcification is common in CRF pa-tients undergoing maintenance hemodialysis,and age,dialysis duration,P,IL-13,FGF23,and SOST are influencing factors for vascular calcification.
