Correlations of serum hsa_circ_0002348 and hsa_circ_0001740 levels with severity of gestational hypertension
- VernacularTitle:血清hsa_circ_0002348、hsa_circ_0001740 水平与妊娠期高血压严重程度的相关性研究
- Author:
Xuemei WANG
1
;
Dechun LIU
;
Shenglan WANG
Author Information
- Keywords: hsa_circ_0002348; hsa_circ_0001740; gestational hypertension; preeclampsia; systolic blood pressure; diastolic blood pressure; human chorionic trophoblast cells; circular RNA
- From: Journal of Clinical Medicine in Practice 2025;29(5):117-121
- CountryChina
- Language:Chinese
- Abstract: Objective To investigate the correlations of serum hsa_circ_0002348 and hsa_circ_0001740 levels with the severity of gestational hypertension.Methods A total of 169 patients with gestational hypertension in the hospital from January 2018 to January 2023 were selected as study group,and they were divided into mild preeclampsia group(n=82),severe preeclampsia group(n=47),and eclampsia group(n=40)according to the severity of the disease.Another 169 healthy pregnant women with antenatal examination in the same period were selected as control group.Real-time fluorescent quantitative PCR(qRT-PCR)was used to detect the relative expression levels of serum hsa_circ_0002348 and hsa_circ_0001740.The correlations of serum hsa_circ_0002348 and hsa_circ_0001740 levels with the severity of the disease were analyzed.Receiver operating character-istic(ROC)curve was plotted to analyze the values of serum hsa_circ_0002348 and hsa_circ_0001740 levels in diagnosing eclampsia during pregnancy.Results The systolic and diastolic blood pressures of the control group,mild preeclampsia group,severe preeclampsia group,and eclampsia group were all significantly increased(P＜0.01).The level of serum hsa_circ_0002348 in the eclamp-sia group,severe preeclampsia group,mild preeclampsia group,and control group showed a decreasing trend in sequence,while the level of hsa_circ_0001740 showed an increasing trend in sequence,with significant between-group differences(P＜0.01).The area under the curve(AUC)for diagnosing eclampsia during pregnancy by the combination of serum hsa_circ_0002348 and hsa_circ_0001740 was significantly higher than the AUC for diagnosis by each individual index(Zhsa_circ_0002348:hsa_circ_0002348+hsa_circ_0001740=4.677,P＜0.001;Zhsa_circ_0001740:hsa_circ_0002348+hsa_circ_00017403.579,P＜0.001).Spearman analysis showed that serum hsa_circ_0002348 was positively correla-ted with the severity of the disease(rs=0.751,P＜0.05),while hsa_circ_0001740 was negatively correlated with the severity of the disease(rs=-50.638,P＜0.05).Multivariate Logistic regres-sion analysis showed that systolic blood pressure(OR=2.652),diastolic blood pressure(OR=3.247),hsa_circ_0002348(OR=2.365),and hsa_circ_0001740(OR=0.325)were influen-cing factors of severity of the disease(P＜0.05).Conclusion As the severity of gestational hyper-tension increases,the serum hsa_circ_0002348 level increases significantly,while the hsa_circ_0001740 level decreases significantly.Two indexes are correlated with the severity of gestational hy-pertension.
