Application values of triglyceride and glucose index,metabolic insulin resistance score and triglyceride to high-density lipoprotein cholesterol ratio in patients with acute coronary syndrome complicated with multivessel coronary artery disease
- VernacularTitle:甘油三酯和葡萄糖指数、胰岛素抵抗代谢积分、甘油三酯与高密度脂蛋白胆固醇比值在急性冠状动脉综合征合并多支冠状动脉病变患者中的应用价值
- Author:
Juncong MAO
1
;
Yunfei HONG
;
Yin WEI
;
Yerui CAI
;
Jinsong YIN
Author Information
- Keywords: acute coronary syndrome; multivessel coronary artery disease; triglyceride and glucose index; metabolic insulin resistance score; triglyceride to high-density lipoprotein cholesterol ratio; SYNTAX score
- From: Journal of Clinical Medicine in Practice 2025;29(5):56-63
- CountryChina
- Language:Chinese
- Abstract: Objective To evaluate the predictive abilities of the triglyceride and glucose(TyG)index,metabolic insulin resistance score(METSIR),and ratio of triglyceride to high-density lipopro-tein cholesterol(TG/HDL-C)for the risk of onset and severity of lesions in patients with acute coro-nary syndrome(ACS)complicated with multivessel coronary artery disease.Methods A retrospec-tive analysis was conducted on the clinical data of 260 ACS patients admitted to Yunnan Provincial Third People's Hospital,and the patients were divided into multivessel disease group(n=160)and non-multivessel disease group(n=100);based on the SYNTAX score,the multivessel disease group was further divided into high-risk group with 71 cases(score＞22.5)and low-risk group with 89 cases(score ≤22.5).Results The multivessel disease group had significantly higher proportions of males,history of diabetes,history of smoking,TyG index,METSIR,and TG/HDL-C compared to the non-multivessel disease group(P＜0.05).Correlation analysis showed that the TyG index and TG/HDL-C were significantly positively correlated with the SYNTAX score(P＜0.05),while MET-SIR had no correlation with the SYNTAX score(P＞0.05).Logistic regression analysis indicated that METSIR was an independent risk factor for ACS complicated with multivessel coronary artery disease(P＜0.05),and TyG,METSIR and TG/HDL-C were all independent factors for predicting the severity of lesions(P＜0.05).Receiver operating characteristic(ROC)curve analysis showed that TyG had the highest predictive value for ACS complicated with multivessel coronary artery dis-ease and its severity(area under the curve was 0.804).Conclusion The TyG index,METSIR,and TG/HDL-C are of great significance in the early identification and assessment of ACS complicat-ed with multi vessel coronary artery disease,with TyG having the highest predictive value.
