Research trend and hotspots in cardiovascular immune-related adverse events induced by immune checkpoint inhibitor therapy:a CiteSpace based visual analysis
- VernacularTitle:免疫检查点抑制剂治疗所致心血管免疫相关不良反应的研究趋势和热点——基于CiteSpace的可视化分析
- Author:
Wensen ZHANG
1
;
Zhendong WANG
;
Ying FU
;
Guoda MA
;
Riling CHEN
Author Information
- Keywords: immune checkpoint inhibitors; cardiovascular immune-related adverse events; CiteSpace software; visual analysis; myocarditis; malignancy; monoclonal antibody; bibliometrics
- From: Journal of Clinical Medicine in Practice 2025;29(5):1-8,15
- CountryChina
- Language:Chinese
- Abstract: Objective To conduct a bibliometric and visual analysis of global literature on cardi-ovascular immune-related adverse events(irAEs)induced by immune checkpoint inhibitors(ICIs)in cancer treatment,and to explore the research status,hotspots,and future trends in this field.Meth-ods The Web of Science Core Collection(WOSCC)database was utilized to retrieve and screen rel-evant literature.CiteSpace software was employed for visual analysis of countries,institutions,au-thors,and keywords.Results A total of 1,350 articles were retrieved,with an annual increase in publication volume.The United States dominated in terms of national,institutional,and author contri-butions,while European countries and institutions demonstrated close collaborative networks.Keyword analysis and cited reference mapping revealed an evolution of research hotspots:from initial mechanistic investigations to monoclonal antibody applications,and subsequently to safety concerns.Current lre-search focuses on ICI monoconal antibody combination therapy for malignancies and cardiovascular irAEs,particularly fatal myocarditis,which has emerged as a prominent topic.Conclusion ICIs mon-oclonal antibody therapies and their associated cardiovascular irAEs,especially combination therapies and life-threatening myocarditis,represent key research frontiers.Investigations into drug combination strategies and fatal myocarditis may guide future research directions.
