Effect of ultrasound-guided individualized treatment regimen on outcome of frozen-thawed embryo transfer in patients with adenomyosis
- VernacularTitle:超声引导下个体化治疗方案对子宫腺肌症患者冻融胚胎移植结局的影响
- Author:
Yu ZHANG
1
;
Hongwei YAN
Author Information
- Keywords: adenomyosis; ultrasound-guided; individualized treatment; embryo transfer; es-tradiol; endometrial thickness
- From: Journal of Clinical Medicine in Practice 2025;29(4):114-118
- CountryChina
- Language:Chinese
- Abstract: Objective To explore the impact of ultrasound-guided individualized treatment regimens on the outcomes of frozen-thawed embryo transfer(FET)in patients with adenomyosis.Methods A ret-rospective analysis was conducted on the clinical data of 80 patients with adenomyosis.Based on treat-ment regimen,the patients were divided into observation group and control group,with 40 patients in each group.The observation group received ultrasound-guided individualized treatment,while the con-trol group received conventional treatment.The endometrial thickness,serum hormone levels,embryo implantation rate,clinical pregnancy rate,early miscarriage rate,and live birth rate were compared between the two groups.Receiver operating characteristic(ROC)curves were constructed to assess the predictive value of relevant indicators for embryo transfer outcomes.Results On the day of embryo transfer,the endometrial thickness in the observation group was greater than that in the control group(P＜0.05).On the same day,the serum estradiol and progesterone levels in the observation group were higher than those in the control group(P＜0.05).After embryo transfer,the observation group exhibited higher embryo implantation rate,clinical pregnancy rate,and live birth rate,as well as a lower early miscarriage rate compared with the control group(P＜0.05).The results of ROC curve analysis revealed that the area under the curve(AUC)for the combined prediction of embryo transfer success using endometrial thickness,serum estradiol level,and serum progesterone level was 0.88,which was greater than that of individual predictors(0.64,0.69,and 0.68).Conclusion Ultra-sound-guided individualized treatment regimens can significantly optimize endometrial thickness,im-prove the intrauterine environment,and regulate hormone levels,thereby enhancing the embryo im-plantation rate,clinical pregnancy rate and live birth rate,reducing the early miscarriage rate,and providing an important safeguard for successful fertility in patients with adenomyosis.
