Effects of combined spinal-epidural analgesia on labor pain and stress response in multiparous women in high-altitude region
- VernacularTitle:腰硬联合镇痛对高原地区经产妇分娩疼痛及应激反应的影响
- Author:
Juan TAN
1
;
Danzhiduoji
;
Yao LUO
;
Cangrencijue
;
Na MI
;
Xiaohui CHI
Author Information
- Keywords: combined spinal-epidural analgesia; high-altitude region; multiparous women; labor analgesia; stress levels; maternal and neonatal outcomes
- From: Journal of Clinical Medicine in Practice 2025;29(4):83-86,91
- CountryChina
- Language:Chinese
- Abstract: Objective To investigate the analgesic effect of combined spinal-epidural analgesia and its impact on stress levels in multiparous women during labor in a high-altitude region.Methods A total of 86 multiparous women were enrolled as study subjects.They were divided into observation group(43 cases)and control group(43 cases)based on whether they received labor analgesia.The obser-vation group received combined spinal-epidural analgesia during the first stage of labor.Pain levels[Visual Analogue Scale(VAS)],labor psychological experience[Chinese version of the Childbirth Self-Efficacy Inventory(CBSEI-C32)and Coping with Childbirth(CCB)],stress levels[serum cor-tisol(Cor),norepinephrine(NE)and adiponectin(APN)]as well as maternal and neonatal out-comes were compared between the two groups.Results The VAS scores during the first,second and third stages of labor were significantly lower in the observation group than those in the control group(P＜0.05).The CBSEI-C32 and CCB scores at 24 hours postpartum in the observation group were significantly higher than those in the control group(P＜0.05).The serum levels of Cor,NE and APN at 12 hours postpartum in the observation group were significantly lower than those in the control group(P＜0.05).The incidence of adverse maternal and neonatal outcomes in the observation group was 0％,which was significantly lower than 9.30％in the control group(P＜0.05).Con-clusion In high-altitude regions,combined spinal-epidural analgesia is effective in reducing labor pain,improving labor psychological experience,lowering stress levels,and reducing adverse maternal and neonatal outcomes in multiparous women.
