Relationships of serum tumor necrosis factor-α and glycated hemoglobin levels with painful diabetic neuropathy
- VernacularTitle:血清肿瘤坏死因子-α、糖化血红蛋白水平与痛性糖尿病神经病变的关系研究
- Author:
Xiaowei LIU
1
;
Juan PAN
;
Jing LI
;
Hui LI
Author Information
- Keywords: painful diabetic neuropathy; tumor necrosis factor-α; glycated hemoglobin; C-reactive protein; duration of disease
- From: Journal of Clinical Medicine in Practice 2025;29(4):50-54
- CountryChina
- Language:Chinese
- Abstract: Objective To investigate the relationships of tumor necrosis factor-α(TNF-α)and glycated hemoglobin(HbA1c)with the occurrence of painful diabetic neuropathy(PDN)in patients with type 2 diabetes mellitus(T2DM).Methods A total of 225 patients with T2DM were enrolled and divided into PDN group(52 patients)and non-PDN group(173 patients)based on the presence of PDN.Clinical data of the two groups were collected and compared.A multivariate Logistic regres-sion model was used to analyze risk factors for PDN,and a receiver operating characteristic(ROC)curve was plotted to assess the predictive value of TNF-α and HbA1c for PDN in T2DM patients.Results Patients in the PDN group had a longer duration of T2DM,higher levels of fasting blood glu-cose(FBG),HbA1c,C-reactive protein(CRP),and TNF-α compared with the non-PDN group(P＜0.05).Multivariate Logistic regression analysis showed that a longer duration of T2DM,higher TNF-α levels,and higher HbA1c levels were independent risk factors for PDN in T2DM patients(P＜0.05,OR＞1).ROC curve analysis revealed that the area under the curve for the combined predic-tion of PDN in T2DM patients by TNF-α and HbA1c was 0.877(95％CI,0.826 to 0.916),which was greater than that of TNF-α and HbA1c alone[0.684(95％CI,0.619 to 0.745)and 0.764(95％CI,0.703 to 0.818),respectively].Conclusion High serum levels of TNF-α and HbA1c are independent risk factors for PDN in T2DM patients,and the combined detection of two biomarkers has high predictive efficacy for the risk of PDN in T2DM patients.
