Relationship between serum regulatory T cell-related factors and pain mediators in patients with diabetic peripheral neuropathy
- VernacularTitle:糖尿病周围神经病变患者血清调节性T细胞相关因子与疼痛介质的关系
- Author:
Panmei LIU
1
;
Xiaochong FAN
;
Qingying LIU
;
Minyu MA
Author Information
- Keywords: diabetic peripheral neuropathy; regulatory T cells; pain mediators; neuropathic pain
- From: Journal of Clinical Medicine in Practice 2025;29(4):34-37,43
- CountryChina
- Language:Chinese
- Abstract: Objective To investigate the dynamic changes of serum regulatory T cell(Treg cell)-related factors in patients with diabetic peripheral neuropathy(DPN)and their relationships with pain mediators.Methods A total of 140 patients with DPN were enrolled and divided into painful DPN group(36 patients)and painless DPN group(104 patients)based on the presence of neuropathic pain.The serum levels of Treg cell-related factors[interleukin-10(IL-10),transforming growth fac-tor-β1(TGF-β1),interleukin-35(IL-35)]and pain mediators[prostaglandin E2(PGE2),hista-mine(His),and 5-hydroxytryptamine(5-HT)]between the two groups were compared.Pearson cor-relation analysis was used to explore the correlations of the serum levels of IL-10,TGF-β1,and IL-35 with the levels of PGE2,His,and 5-HT in patients with DPN.Multiple linear regression analysis was conducted to investigate the influencing factors of pain intensity in patients with DPN.Results The serum levels of TGF-β1,PGE2,His,and 5-HT were higher,while the levels of IL-10 and IL-35 were lower in the painful DPN group than those in the painless DPN group(P＜0.05).Pearson correlation a-nalysis showed that IL-10 was negatively correlated with PGE2,His,and 5-HT(r=-0.781,-0.794,-0.714,P＜0.05);TGF-β1 was positively correlated with PGE2,His,and 5-HT(r=0.605,0.590,0.515,P＜0.05);IL-35 was negatively correlated with PGE2,His,and 5-HT(r=-0.727,-0.847,-0.727,P＜0.05).Multiple linear regression analysis revealed that IL-10,TGF-β1,and IL-35 were closely related to the pain intensity in patients with DPN and were influencing factors of painin-tensity(P＜0.05).Conclusion The serum levels of IL-10 and IL-35 in patients with DPN are negatively correlated with the levels of PGE2,His,and 5-HT,while the level of TGF-β1 is positive-ly correlated with these pain mediators.Furthermore,IL-10,TGF-β1,and IL-35 are closely related to the degree of neuropathic pain in patients with DPN.
