Effect of Siwu Wuzi Decoction on vascular endothelial growth factor,transforming growth factor-β1 and inflammatory factor levels in patients with wet age-related macular degeneration
10.7619/jcmp.20244475
- VernacularTitle:四物五子汤治疗湿性年龄相关性黄斑变性对血管内皮生长因子、转化生长因子-β1及炎性因子水平的影响
- Author:
Kaiyue MA
1
;
Shu ZHANG
;
Shixin HUANG
;
Xiaobo LI
Author Information
1. 北京中医药大学中药学院,北京,102488
- Keywords:
Siwu Wuzi Decoction;
conbercept;
photodynamic therapy;
wet age-related mac-ular degeneration;
vascular endothelial growth factor;
transforming growth factor-β1;
inflammatory factors
- From:
Journal of Clinical Medicine in Practice
2025;29(4):6-10
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of Siwu Wuzi Decoction in the treatment of wet age-related macular degeneration(wAMD)on the levels of vascular endothelial growth factor(VEGF),transforming growth factor-β1(TGF-β1),and inflammatory factors in patients.Methods A total of 216 patients with wAMD were randomly divided into western medicine group(n=108)and integrated Chinese and western medicine group(n=108).The western medicine group received conbercept plus photodynamic therapy(PDT),while the integrated Chinese and western medicine group received con-bercept,PDT,and Siwu Wuzi Decoction.Both groups were treated for 3 months.The traditional Chi-nese medicine syndrome scores,best-corrected visual acuity(BCVA),intraocular pressure,VEGF,TGF-β1,inflammatory factor levels[interleukin(IL)-6,IL-13],quality of life[Chinese Low Vision Quality of Life Scale(CLVQOL)],and clinical efficacy were observed in both groups.Results After treatment,the traditional Chinese medicine syndrome scores decreased in both groups,with the scores in the integrated Chinese and western medicine group being lower than those in the western medicine group(P＜0.05).After treatment,BCVA decreased in both groups,with the BCVA in the integrated Chinese and western medicine group being lower than that in the western medicine group(P＜0.05).After treatment,intraocular pressure increased in both groups,but the intraocu-lar pressure in the integrated Chinese and western medicine group was lower than that in the western medicine group(P＜0.05).After treatment,VEGF and TGF-β1 levels decreased in both groups,with the levels in the integrated Chinese and western medicine group being lower than those in the western medicine group(P＜0.05).After treatment,IL-6 and IL-13 levels decreased in both groups,with the levels in the integrated Chinese and western medicine group being lower than those in the western medicine group(P＜0.05).After treatment,CLVQOL scores increased in both groups,with the scores in the integrated Chinese and western medicine group being higher than those in the western medicine group(P＜0.05).The total effective rate of treatment in the integrat-ed Chinese and western medicine group was 97.22％,which was higher than 85.19％in the west-ern medicine group(P＜0.05).Conclusion Siwu Wuzi Decoction has a good therapeutic effect on wAMD,which can alleviate symptoms,restore vision,reduce intraocular pressure,regulate VEGF,TGF-β1,and inflammatory factor levels,and improve quality of life.
