A large sample cross-sectional study of the relationship between relative fat mass index and gallstones in adults based on the NHANES database
- VernacularTitle:基于NHANES数据库的相对脂肪质量指数与成年人胆结石关系的大样本横断面研究
- Author:
Zhenfang SHENG
1
;
Zhaoxiang WANG
;
Shao ZHONG
;
Fengyan TANG
Author Information
- Keywords: obesity; relative fat mass; gallstones; adult population; cross-sectional study
- From: Journal of Clinical Medicine in Practice 2025;29(2):108-113,118
- CountryChina
- Language:Chinese
- Abstract: Objective To analyze the association between relative fat mass index(RFM)and the risk of gallstones in adults.Methods Adult participants from the National Health and Nutrition Examination Survey(NHANES)were included.RFM was calculated based on the participants'height and waist circumference.The history of gallstone disease was obtained through self-reports.The relationship between RFM and the risk of gallstones was assessed using Logistic regression analy-sis,smooth curve fitting and subgroup analysis.Results A total of 4,874 participants were includ-ed in the study.The RFM level of gallstone subjects was significantly higher than that of non-gallstone subjects(P＜0.001).After adjusting for various confounders,RFM level was found to be independ-ently associated with the risk of gallstones(OR=1.095,95％CI:1.022 to 1.173,P=0.010).Smooth curve fitting analysis indicated that the risk of gallstone disease also increased as RFM levels increased.The results of subgroup analysis showed no significant differences in the relationship be-tween RFM and gallstones across different populations.Conclusion Higher RFM level is associated with an increased risk of gallstones in participants.RFM may serve as an economical,effective and convenient indicator for assessing the risk of gallstones,but further prospective studies are required to validate these findings.
