Research progress on relationship between blood-brain barrier and pancreatic encephalopathy
- VernacularTitle:血脑屏障与胰性脑病关系的研究进展
- Author:
Jialin LI
1
;
Dan LUO
Author Information
- Keywords: pancreatic encephalopathy; severe acute pancreatitis; blood-brain barrier; brain microvascular endothelial cells; tight junction structures; inflammatory factors; gut microbiota
- From: Journal of Clinical Medicine in Practice 2025;29(1):144-148
- CountryChina
- Language:Chinese
- Abstract: Severe acute pancreatitis(SAP)is a common acute abdominal condition,with pan-creatic encephalopathy(PE)being one of its complications,characterized by central nervous system(CNS)lesions when pancreatic inflammation occur.The blood-brain barrier(BBB),serving as a physical and biochemical barrier between peripheral circulation and the CNS,plays a crucial role in maintaining the stable microenvironment of the CNS.Damage to the BBB can lead to secondary cere-bral edema in SAP patients.Investigating the relationship between BBB and SAP can provide new in-sights into the prevention and treatment of PE.This review summarized the cellular composition,bas-ic structure,and physiological functions,as well as the current research status of inflammatory factors and gut microbiota in the course of PE in adjusting BBB,exploring the patterns of BBB changes dur-ing the onset and progression of PE.
