Research progress in microRNAs as potential biomarkers in temporal lobe epilepsy
- VernacularTitle:微小RNA作为颞叶癫痫潜在生物标志物的研究进展
- Author:
Liya FANG
1
;
Yuanyuan LIU
;
Jiahao LIU
;
Jiawei LI
;
Pei ZENG
;
Jin GUO
Author Information
- Keywords: microRNA; temporal lobe epilepsy; biomarker; non-coding RNA; differential ex-pression; neuroinflammation
- From: Journal of Clinical Medicine in Practice 2025;29(1):130-135
- CountryChina
- Language:Chinese
- Abstract: Temporal lobe epilepsy(TLE)is the most common form of focal epilepsy in adults,characterized by spontaneous recurrent seizures,with most patients experiencing drug resistance and cognitive dysfunction.MicroRNAs(miRNAs)play a critical role in the pathological process of TLE through their regulation of post-transcriptional gene expression.The pathogenesis of TLE has not been fully elucidated,lacking effective clinical therapeutic targets and prognostic markers.This review sum-marized the expression changes of miRNAs in TLE and their research progress as potential biomarkers,aiming to provide new insights into the early diagnosis,prognosis evaluation,and pathogenic mecha-nisms of TLE.
