Expression and clinical significance of right open reading frame kinase 2 and programmed death-ligand 1 in brain gliomas
- VernacularTitle:右开放阅读框激酶2、程序性死亡受体-配体1在脑胶质瘤中的表达及临床意义
- Author:
Qing LEI
1
;
Yu WANG
Author Information
- Keywords: brain glioma; right open reading frame kinase 2; programmed death-ligand 1; distant metastasis; prognosis
- From: Journal of Clinical Medicine in Practice 2025;29(1):1-5,12
- CountryChina
- Language:Chinese
- Abstract: Objective To investigate the expression of right open reading frame kinase 2(RIOK2)and programmed death-ligand 1(PD-L1)in brain gliomas and their relationships with clin-icopathological features and prognosis.Methods A total of 139 patients with brain gliomas were en-rolled in this study.Brain glioma tissues and adjacent normal tissues were collected intraoperatively.The expression of RIOK2 and PD-L1 was detected by immunohistochemical staining,and their rela-tionships with clinicopathological features and prognosis were analyzed.Results The positive expres-sion rates of RIOK2 and PD-L1 in brain glioma tissues were 76.26％and 72.66％,respectively,which were significantly higher than 15.11％and 18.71％in adjacent tissues(P＜0.05).Univari-ate analysis showed that the positive expression of RIOK2 and PD-L1 in brain glioma tissues was relat-ed to distant metastasis and World Health Organization(WHO)grading(P＜0.05),but showed no correlations with age,gender,tumor diameter,tumor location,or tumor type(P＞0.05).Multivari-ate Logistic regression analysis revealed that high WHO grading,distant metastasis,positive expres-sion of RIOK2,and positive expression of PD-L1 were independent risk factors for poor prognosis in patients with brain gliomas(P＜0.05).The 3-year follow-up results showed that 96 patients survived and 43 patients died.The positive expression rates of RIOK2 and PD-L1 in surviving patients were lower than those in deceased patients(P＜0.05).Conclusion RIOK2 and PD-L1 are highly expressed in brain glioma tissues and are closely related to WHO grading and distant metastasis.Patients with brain gliomas who have lower positive expression rates of RIOK2 and PD-L1 have a better prognosis compared to those with higher positive expression rates.
