META-ANALYSIS OF ACCURACY OF DIAGNOSTIC TESTS FOR CLONORCHIASIS
10.3969/j.issn.1005-0507.2025.03.002
- VernacularTitle:华支睾吸虫病诊断试验准确性的Meta分析
- Author:
Zi-Han CAI
1
;
Yu-Yang ZHOU
;
Qiong WU
;
Jing ZHOU
;
Yi-Mei YANG
Author Information
1. 泗阳医院检验科,江苏泗阳 223700
- Keywords:
Clonorchiasis;
Meta-analysis;
Clonorchis sinensis;
Diagnostic test
- From:
Acta Parasitologica et Medica Entomologica Sinica
2025;32(3):138-145
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy of the enzyme-linked immunosorbent assay(ELISA),polymerase chain reaction(PCR),and gold chromatographic strip assay(GICA)in diagnosing clonorchiasis through a meta-analysis of diagnostic tests.Methods Relevant databases,including CNKI,the Wan Fang Database,VIP,and PubMed,were searched according to inclusion and exclusion criteria.Literature quality was assessed using RevMan 5.4 and Stata 18,and funnel plots,forest plots,and SROC curves were generated.Results A total of 50 articles met the inclusion criteria.Deeks'funnel plot analysis indicated no significant publication bias among the three methods.The combined effect size analysis revealed that the sensitivity and specificity of ELISA for detecting clonorchiasis were 0.93(0.89-0.95)and 0.94(0.92-0.96),respectively,with an area under the SROC curve of 0.98.For PCR,the sensitivity and specificity were 0.93(0.84-0.97)and 0.92(0.80-0.97),respectively,yielding an area under the SROC curve of 0.97.The sensitivity and specificity of the GICA method for detecting clonorchiasis were 0.91(0.83-0.96)and 0.95(0.87-0.98),respectively,with an area under the SROC curve of 0.97.Conclusions In the diagnosis of clonorchiasis,ELISA,PCR and GICA have high diagnostic value,but their ranges differ from each other.
