RESEARCH PROGRESS ON INNATE IMMUNE REGULATORY MECHANISMS IN INSECTS

VernacularTitle:昆虫先天免疫调控机制的研究进展
Author: Shun-Cai BAO ¹ ; Xue LU ; Xiao-Hui HOU
Author Information

1. 遵义医科大学基础医学院细胞生物学教研室,贵州遵义 563099
Keywords: Insect immunity; Innate immune pathway; Cellular immunity; Humoral immunity; Melanization reaction
From: Acta Parasitologica et Medica Entomologica Sinica 2024;31(2):115-122
CountryChina
Language:Chinese
Abstract: Insects frequently encounter microbial infections in their natural environment.Infections such as viruses carried by vector arthropods can cause serious human illness or animal epidemics.However,insects rely primarily on their innate immune system to defend themselves against pathogenic infections.Based on its structure and effector mechanisms,the immune system primarily comprises cellular and humoral immunity.Cellular immunity involves phagocytosis,agglutination,and encapsulation,carried out by hemocytes.Humoral immunity mostly depends on immunological proteins generated by adipose cells to protect against infections using antimicrobial peptides or melanization reactions.Antimicrobial peptide synthesis contributed significantly to specific immune signalling pathways including Toll,IMD and JAK/STAT.Studying insects'natural defences would help develop new ways to protect humans and animals from vector-borne diseases.