ANALYSIS OF THE CLINICAL FEATURES OF 4 PATIENTS WITH DETECTABLE SEVERE FEVER WITH THROMBOCYTOPENIA SYNDROME VIRUS IN THEIR THROAT SWABS
10.3969/j.issn.1005-0507.2016.01.004
- VernacularTitle:四例咽拭子检测阳性发热伴血小板减少综合征重症患者的临床特征分析?
- Author:
JianGong HU
1
;
Wei PENG
;
Yi SUN
;
Ning CUI
;
ChenTao GUO
;
QingBin LU
;
ZhenDong YANG
;
LiYuan WANG
;
XiaoAi ZHANG
;
Wei LIU
Author Information
1. 军事医学科学院微生物流行病研究所,病原微生物生物安全国家重点实验室,北京100071
- Keywords:
Severe fever with thrombocytopenia syndrome;
RT-PCR;
Transmission routes;
Throat swab
- From:
Acta Parasitologica et Medica Entomologica Sinica
2016;23(1):21-27
- CountryChina
- Language:Chinese
-
Abstract:
The suspected severe fever with thrombocytopenia syndrome ( SFTS) cases of pharyngeal swab detection of severe fever with thrombocytopenia syndrome virus ( SFTSV) , to discuss the possibility of spread of respiratory tract. According to the suspected cases of inclusive criteria from national Ministry of Health issued " National guideline for prevention and control of severe fever with thrombocytopenia syndrome (2010)". May to September in 2013, we collect serum and throat swab of 72 suspected SFTS cases from the sentinel surveillance hospital in SFTS high?incidence area ( Xinyang, He′nan Province) . Real?time RT?PCR and ELISA methods for the detection of SFTSV were used in this study. In 72 suspected SFTS cases, 52 (72?2%) were detected positive, 46 were positive for RT?PCR, 6 were positive for ELISA. In 52 SFTSV positive cases, 4 ( 7?7%) cases were found with positive nuclei acid of SFTSV in throat swab samples. in 20 SFTSV negative cases, all the throat swab samples from the patients were also negative. The 4 SFTSV positive cases were severe, with cough and the highest viral load of up to 108 copies/mL. SFTSV can be detected in the throat swabs from patients, and the positive rate of throat swabs is much lower than that of serum samples. The feasibility of detecting SFTSV is disputable. SFTS patients with positive throat swab samples possessed the high viral load and cough symptoms, which may increase the risk of SFTSV transmission through the respiratory tract.
