PATHOGENICITY AND IMMUNOGENICITY OF EIMERIA INTESTINALIS ZHANGJIAKOU ISOLATE
10.3969/j.issn.1005-0507.2014.04.008
- VernacularTitle:肠艾美耳球虫张家口分离株致病性和免疫原性的初步研究
- Author:
Chao LI
1
;
Yun-Zhou WANG
;
Ge-Ru TAO
;
Dan WANG
;
Ya-Qing JIAO
;
Xiao-Long GU
;
Xun SUO
;
Xian-Yong LIU
Author Information
1. 中国农业大学动物医学院,北京100193
- Keywords:
Eimeria intestinalis;
Pathogenicity;
Immunogenicity
- From:
Acta Parasitologica et Medica Entomologica Sinica
2014;(4):258-262
- CountryChina
- Language:Chinese
-
Abstract:
Eimeria intestinalis is one relatively high pathogenic specie of rabbit coccidia.Fully understanding of its biological characteristics makes great contribution to the control of rabbit coccidiosis.In this study, the pathogenicity and immunogenicity of E.intestinalis ZJK strain was studied on weaning rabbits by investigating clinical syndrome, body weight loss and oocyst output.Four groups of rabbits were inoculated with sporulated oocysts in the dose of 0, 1 ×104 , 1 ×105 and 1 ×106, respectively.Then these rabbits were challenged with 1 ×106 oocysts 21 days post inoculation.The results show that the infection with 1 ×104 oocysts was sufficient to cause clinical syndrome and body weight loss, compared with the control group.And the groups given more oocysts show worse symptom.After challenge, no difference of the body weight gain was seen between non-infected control group and immunized groups; meanwhile, the oocyst output of the immunized rabbits was much lower than that of the non-immunized but challenged control group.These results suggest that E. intestinalis ZJK strain is of mediate pathogenicity and excellent immunogenicity. Therefore, a precocious line of E. intestinalis based on this strain can be a suitable candidate for the development of a live attenuated vaccine for rabbit coccidiosis.
