SYSTEMIC CELLULAR IMMUNE RESPONSES IN MICE CHRONICALLY INFECTED BY TOXOPLASMA GONDII CYSTS
10.3969/j.issn.1005-0507.2014.04.001
- VernacularTitle:弓形虫慢性感染小鼠的系统性细胞免疫应答规律
- Author:
Qing YIN
1
;
Xin-Xin ZHAO
;
Xin-Lei YAN
;
Xian-Yong LIU
;
Xun SUO
Author Information
1. 中国农业大学动物医学院,北京100193
- Keywords:
Toxoplasma gondii;
Chronic infection;
Systemic immune response;
T cell
- From:
Acta Parasitologica et Medica Entomologica Sinica
2014;(4):221-226
- CountryChina
- Language:Chinese
-
Abstract:
Toxoplasma gondii infection elicits a Th1-biased inflammatory response.As the protection induced by T.gondii vaccine is highly correlated with the systemic T-cell immune response, here we detected the cellular immune responses in chronically infected BALB/c mice.Splenocytes collected from chronically infected mice exhibited stronger lymphocyte proliferation after the stimulation of cells with soluble tachyzoite antigens.What is more, IFN-γsecretion was detected in CD3 +T, CD4 +T and CD8 +T cells after the stimulation of splenocytes with antigens.In summary, T.gondii chronic infected mice showed stronger systemic T-cell immune response, which would provide valuable data for the evaluation of the efficiency of T.gondii vaccine.
