TACE combined with CBCT-guided MWA simultaneous treatment for small hepatocellular carcinoma:analysis of clinical efficacy and safety
10.3969/j.issn.1008-794X.2025.12.007
- VernacularTitle:TACE联合CBCT引导下MWA同步治疗小肝癌的临床疗效与安全性分析
- Author:
Bin YU
1
;
Yu YIN
;
Jun YANG
;
Pengchen TIAN
;
Lin XU
;
Jia'an DING
;
Xiaoyun MIAO
;
Caifang NI
Author Information
1. 215006 江苏苏州 苏州大学附属第一医院介入科
- Keywords:
transarterial chemoembolization;
cone-beam computed tomography;
micro wave ablation;
hepatocellular carcinoma;
combination treatment
- From:
Journal of Interventional Radiology
2025;34(12):1321-1327
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical efficacy and safety of simultaneous treatment of small hepatocellular carcinoma(HCC)with transarterial chemoembolization(TACE)combined with cone-beam computed tomography-guided(CBCT-guided)microwave ablation(MWA).Methods The clinical data of 69 patients with small HCC(72 lesions in total),who underwent TACE combined with CBCT-guided MWA simultaneous treatment from March 2018 to December 2022 at First Affiliated Hospital of Soochow University hospital,were retrospectively analyzed.Follow-up check was performed at 1,3,6,and 12 months after treatment.The mRECIST criteria was used to evaluate the tumor response.The objective response rate(ORR),disease control rate(DCR),progression-free survival(PFS),local tumor progression(LTP),and adverse reactions were analyzed.Results The initial complete remission(CR)rate,ORR and DCR of TACE combined with CBCT-guided MWA simultaneous treatment for small HCC was 94.2％(65/69),100％and 100％respectively.44.9％(31/69)of patients experienced tumor progression,and 20.3％(14/69)of patients experienced local tumor progression.Univariate and multivariate analyses showed that the maximum tumor diameter(≥2 cm and＜3 cm)was the main risk factor for PFS(HR=4.498,P＜0.001).No serious adverse events occurred during the study.Conclusion TACE combined with CBCT-guided MWA simultaneous treatment for small HCC is clinically effect and safe,and this therapy is particularly suitable for the treatment of lesions where the use of traditional image-guided methods is limited.
