Application and research progress of liquid embolic agents
10.3969/j.issn.1008-794X.2025.12.001
- VernacularTitle:液体栓塞剂应用及其研究进展
- Author:
Yong JIN
1
;
Hao ZHANG
;
Yongde CHENG
Author Information
1. 215004 江苏苏州 苏州大学附属第二医院介入科
- Keywords:
liquid embolic agent;
interventional radiology;
iodized oil;
sclerosing agent;
chemical glue;
personalized treatment;
biocompatibility
- From:
Journal of Interventional Radiology
2025;34(12):1285-1292
- CountryChina
- Language:Chinese
-
Abstract:
Since the 1960s,with the rapid development of interventional radiology technology,liquid embolic agents have become important embolic materials for treating diseases such as tumors,bleeding,and vascular malformations.This article systematically introduces the types of commonly used liquid embolic agents,including iodized oil,hardening agents(such as absolute alcohol and polyvinyl alcohol),cyanoacrylates(such as NBCA and Glubran glue),and ethylene vinyl alcohols(such as Onyx),and analyzes in detail the embolic mechanisms,clinical applications,advantages,and operational limitations of each embolic agent.This article also introduces new liquid embolic agents that have emerged in recent years,including new polymeric agents(such as Magic GlueTM),precipitants(such as Squid and PHIL),phase-change agents(such as GPX)and temperature-sensitive hydrogels(such as TepushenTM),etc.These new materials have achieved significant improvements in biocompatibility,operational flexibility,and clinical efficacy.In addition,this article also discusses the application prospects of liquid embolic agents in controlling acute and chronic bleeding,comprehensive interventional therapy for tumors,treatment of complex vascular malformations,and treatment of visceral aneurysms.Finally,this article points out that future research on liquid embolic agents should focus on the development of new materials,the combination of multimodal treatment methods,the fusion of drug carriers,the application of artificial intelligence and image-guided technology,and personalized design of embolic agent,etc.so as to further enhance the clinical efficacy and safety of liquid embolic agents.
