The serum inflammation and depression indexes,and the therapeutic effect in patients with anxiety-depression after PCI for coronary artery disease treated with Chinese herbs based on the"heart-liver"theory of traditional Chinese medicine:a meta-analysis
10.3969/j.issn.1008-794X.2025.11.015
- VernacularTitle:Meta分析基于"心肝"论治的中药对冠心病PCI术后焦虑抑郁患者的疗效
- Author:
Ruihuan ZHANG
1
;
Tao HAO
;
Jun CHEN
Author Information
1. 719000 陕西榆林 榆林市中医医院脑病科
- Keywords:
treatment based on"heart-liver"theory of traditional Chinese medicine;
Chinese herb;
percutaneous coronary intervention;
anxiety-depression;
serum indicator;
meta-analysis
- From:
Journal of Interventional Radiology
2025;34(11):1245-1253
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the indicators of serum inflammation and depression in patients with anxiety-depression after PCI for coronary heart disease(CHD),who were treated with Chinese herbs based on the"heart-liver"theory of traditional Chinese medicine(TCM),and to analyze the curative effect.Methods A computerized retrieval of clinical randomized controlled trials(RCTs)concerning the Chinese herbs therapy based on the"heart-liver"theory of TCM for patients with anxiety-depression after PCI for CHD from the databases of SinoMed,CNKI,Wanfang,VIP,PubMed and Cochrane Library was conducted.The patients of control group received basic treatment for CHD combined with anti-anxiety and depression treatment,while the patients of TCM group received basic treatment for CHD plus Chinese herbs therapy based on the"heart-liver"theory of TCM or received additional Chinese herbs therapy based on the"heart-liver"theory of TCM on the basis of the same treatment regimen as the control group adopted.The retrieval time period was from the establishment of the database to December 30,2023.RevMan 5.4 software was used to make meta-analysis.TSA 0.9.5.1 Beta software was used to make sequential analysis of trials.Results A total of 8 RCTs were included in this study,involving 919 patients.The results of meta-analysis showed that in TCM group the serum inflammatory indicators including serum hs-CRP content,IL-6 content,TNF content,serum MPO content were lower than those in the control group(P＜0.05);the serum depression indicators including serum 5-HT content and BDNF content were higher than those in the control group(P＜0.05).Based on the above results of the serum indicator analysis,the total effective rate in TCM group was higher than that in the control group(P＜0.05).The assessment of disease improvement degree including TCM syndrome score,anxiety scale score,and depression scale score in TCM group were lower than those in the control group(P＜0.05).The trial sequential analysis indicated that the sample size effect strength of the total effective rate met the requirements expected from meta-analysis and excluded the possibility of false positives.Conclusion For patients with anxiety-depression after PCI for CHD,Chinese herbs therapy based on the"heart-liver"theory of TCM is superior to basic treatment for CHD combined with anti-anxiety and depression treatment in improving serum inflammation and depression indicators with reliable therapeutic efficacy.
