Application of CT myocardial perfusion imaging combined with plaque quantification technique in assessing reperfusion injury in patients with myocardial ischemia
10.3969/j.issn.1008-794X.2025.11.004
- VernacularTitle:CT心肌灌注成像联合斑块定量技术对心肌缺血患者再灌注损伤的评估分析
- Author:
Longtao WANG
1
;
Shuo LIU
;
Tao ZHANG
;
Xu ZHANG
Author Information
1. 830002 新疆乌鲁木齐 新疆维吾尔自治区人民医院放射影像中心
- Keywords:
computed tomography;
myocardial perfusion imaging;
plaque quantification technique;
myocardial ischemia;
reperfusion injury
- From:
Journal of Interventional Radiology
2025;34(11):1185-1190
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the application of CT myocardial perfusion imaging(CT-MPI)combined with plaque quantification technique in assessing reperfusion injury in patients with myocardial ischemia.Methods The clinical data of 100 patients with myocardial ischemia,who were admitted to the People's Hospital of Xinjiang Uygur Autonomous Region of China from June 2019 to June 2024,were retrospectively analyzed.CT-MPI and plaque quantification technique examination were performed in all patients before percutaneous coronary intervention(PCI).According to the presence or absence of reperfusion injury after PCI,the patients were divided into non-injury group(n=38)and injury group(n=62).The CT-MPI parameters,including time-to-peak(TTP),myocardial blood flow(MBF)and myocardial blood volume(MBV),and the plaque quantification technique parameters,including eccentricity index(EI),remodeling index(RI),calcified plaque volume(CPV),minimum lumen area(MLA),narrowness degree(ND),non-calcified plaque volume(NCPV),total plaque volume(TPV)and plaque length(PL),were compared between the two groups.Receiver operating characteristic(ROC)curve was used to analyze the value of CT-MPI and plaque quantification technique in assessing reperfusion injury in patients with myocardial ischemia,and logistic regression analysis was used to determine the factors influencing reperfusion injury.Results TTP in the injury group was longer than that in the non-injury group,while MBF and MBV in the injury group were lower than those in the non-injury group(all P＜0.05).No statistically significant differences in El,RI,CPV and MLA existed between the two groups(all P＞0.05).ND,NCPV,TPV and PL in the injury group were higher than those in the non-injury group(P＜0.001).ROC curve analysis showed that the area under ROC curve(AUC)of combination use of TTP MBF,MBV,ND,NCPV,TPV and PL for evaluating reperfusion injury in patients with myocardial ischemia was 0.914,which was higher than the values obtained by the separate evaluation of the above seven indicators,and the results were 0.781,0.784,0.760,0.791,0.775,0.792 and 0.798 respectively(all P＜0.05).Logistic regression analysis revealed that TTP,MBF,MBV,ND,NCPV,TPV and PL were the risk factors for reperfusion injury in patients with myocardial ischemia(all P＜0.05).Conclusion CT-MPI combined with plaque quantification technique can effectively evaluate the reperfusion injury in patients with myocardial ischemia,providing important reference for the diagnosis and treatment of reperfusion injury,therefore,it has high clinical application value.
