Latest advance in the biodegradable stent in neurointerventional therapy
10.3969/j.issn.1008-794X.2025.10.002
- VernacularTitle:可降解支架在神经介入治疗中的最新进展
- Author:
Hui XU
1
;
Rui ZHAO
;
Jianmin LIU
Author Information
1. 200093 上海 上海理工大学健康科学与工程学院
- Keywords:
neurointervention;
biodegradable stent;
stent used for stenosis;
flow-diverter devise
- From:
Journal of Interventional Radiology
2025;34(10):1043-1047
- CountryChina
- Language:Chinese
-
Abstract:
With the development of medical technology and interventional equipment,neurointervention has become an important treatment method for cerebrovascular diseases.Intravascular stenting plays a crucial role in the treatment of cerebral artery stenosis and intracranial aneurysms,and its clinical efficacy and safety are constantly improving.However,as the neurointervention enters the mature stage,the long-term effect of the interventional materials placed within the brain and the problem of the non-degradable nature of the stent material have got obvious concern in clinical practice.The application of biodegradable materials holds promise for solving this dilemma,as their degradation products can be absorbed or excreted by the body.The development history of the biodegradable stents shows that biodegradable stents began to be studied as early as in the 1980s.Due to the features of intracranial arteries,the stents used for intracranial stenosis have to meet higher clinical requirements in terms of flexibility,precision and the influence of degradation products,which are still studied by animal experiment and preliminary clinical research.Flow-diverter devises have already achieved definite clinical effect.Due to the disadvantages of conventional metal stents,such as artifacts,which have a long-term influence on the imaging quality,the degradable flow-diverter devices have become a current research hot spot,the materials include metal,metal-polymer mixture,polymer,etc.Researchers are still exploring the material selection,control of degradation time and optimization of pore density.In conclusion,biodegradable stents used for intracranial stenosis and biodegradable flow-diverter devices have broad application prospects,although more studies are need to be conducted before biodegradable stents can be widely used in clinical practice.
