Hypofractionated radiotherapy combined with transcatheter arterial chemoembolization for the treatment of metachronous hepatic oligometastasis from nasopharyngeal carcinoma:analysis of its clinical effect
10.3969/j.issn.1008-794X.2025.09.015
- VernacularTitle:大分割放疗联合经导管动脉化疗栓塞治疗鼻咽癌异时性肝寡转移临床效果分析
- Author:
Yecai HUANG
1
;
Jie ZHOU
;
Peng ZHANG
;
Shun LU
;
Jingyi LANG
;
Guohui XU
;
Xuegang YANG
Author Information
1. 610041 四川成都 四川省肿瘤医院·研究所肿瘤精准放疗四川省重点实验室,四川省肿瘤临床医学研究中心、四川省癌症防治中心、电子科技大学附属肿瘤医院放疗科
- Keywords:
nasopharyngeal carcinoma;
hepatic metastasis;
hypofractionated radiotherapy;
transcatheter arterial chemoembolization
- From:
Journal of Interventional Radiology
2025;34(9):992-996
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effectiveness and safety of hypofractionated radiotherapy(HFRT)combined with transcatheter arterial chemoembolization(TACE)for metachronous hepatic oligometastasis from nasopharyngeal carcinoma(NPC).Methods The clinical data of patients with metachronous hepatic oligometastasis from NPC,who received HFRT combined with TACE treatment at the Sichuan Provincial Cancer Hospital of China from January 2012 to October 2022,were retrospectively analyzed.The 3-year and 5-year overall survival(OS),progression-free survival(PFS),local recurrence-free survival(LRFS),no extrahepatic distant metastasis survival(EMFS),and treatment-related adverse reactions were analyzed.Results A total of 55 patients were enrolled in this study,including 36 males and 19 females,the median age at the time of occurring metachronous hepatic oligometastasis was 44(27-75)years.The 3-year and 5-year OS,PFS,LRFS,EMFS were 67.8％and 40.0％,55.8％and 30.0％,72.7％and 56.5％,63.6％and 56.5％,respectively.The subgroup analysis indicated that the treatment course of TACE ≥3 cycles could significantly improve the PFS of patients with oligometastasis.HFRT combined with TACE treatment was well tolerated by all patients,and the incidence of Grade Ⅲ-Ⅳadverse reactions was quite low.Conclusion For the treatment of metachronous hepatic oligometastasis from NPC,HFRT combined with TACE is clinically effective,besides,the patients can well tolerate the therapeutic scheme.
