CT-assisted 3D printing template-guided implantation of 125I particles for the treatment of head and neck malignancies:a clinical study
10.3969/j.issn.1008-794X.2025.09.014
- VernacularTitle:3D模板引导125I粒子植入治疗头颈部恶性肿瘤的临床研究
- Author:
Ao LIU
1
;
Xin LI
;
Qin YAN
;
Aihua LUO
Author Information
1. 443000 湖北宜昌 宜昌市第二人民医院胸部肿瘤一病区
- Keywords:
125I particle implantation;
head and neck cancer;
cancerous pain;
quality of life
- From:
Journal of Interventional Radiology
2025;34(9):988-992
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the short-term clinical effect(including curative efficacy,pain relief,and quality of life)of CT-assisted 3D printing template-guided implantation of 125I particles in treating head and neck malignancies.Methods A total of 12 patients with head and neck malignant tumors complicated by moderate to severe cancerous pain,who were admitted to Yichang Municipal second People's Hospital to receive treatment from September 2019 to July 2024,were enrolled in this study.All patients received CT-assisted 3D individualized template-guided implantation of 125I particles therapy.The short-term curative efficacy,pain relief,and quality of life of patients were evaluated.Results Three months after implantation of 125I particles,complete response(CR)was obtained in 3 patients,partial remission(PR)in 5 patients,and stable disease(SD)in 4 patients,with an objective response rate(ORR)of 66.67％and a disease control rate(DCR)of 100％.The preoperative mean NRS score was(5.58±0.79)points,and the postoperative 3-month mean NRS score was(2.08±0.67)points.The postoperative 3-month physiological well-being(PWB),emotional well-being(EWB),functional well-being(FWB),and the total score were significantly better than their preoperative values,the differences were statistically significant(P＜0.05).No statistically significant difference in social/family well-being(SWB)existed between its postoperative 3-month value and its preoperative value.Adverse reactions occurred in 2 patients,including local mucosal ulceration(n=1)and skin redness with swelling(n=1),which were improved after treatment.No serious complications occurred.Conclusion For the treatment of patients with head and neck malignant tumors complicated by moderate to severe cancerous pain,radioactive 125I particle implantation has a significant short-term effect,it can effectively relieve cancerous pain and improve quality of life of patients with reliable clinical safety.
