CT-guided lumbar disc injection of autologous platelet-rich plasma combined with pulsed radiofrequency therapy for discogenic back pain:analysis of its therapeutic effect
10.3969/j.issn.1008-794X.2025.09.013
- VernacularTitle:腰椎间盘内注射自体富血小板血浆联合脉冲射频治疗椎间盘源性腰痛效果分析
- Author:
Guipeng WU
1
;
Xiaoqing XU
;
Yulan SHAN
;
Yuan ZHOU
Author Information
1. 226001 江苏南通 南通大学附属医院疼痛科;海安市人民医院麻醉疼痛科
- Keywords:
platelet-rich plasma;
pulsed radiofrequency;
discogenic back pain
- From:
Journal of Interventional Radiology
2025;34(9):983-987
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the long-term efficacy of intradiscal injection of autologous platelet-rich plasma(PRP)and intradiscal injection of autologous PRP combined with pulsed radiofrequency(PRF)therapy for discogenic back pain(DBP).Methods Prospective inclusion of 98 DBP patients who received treatment at Hai'an People's Hospital from July 2019 to December 2023 was conducted.The patients were randomly divided into study group(receiving PRP combined with PRF,n=50)and control group(receiving PRP only,n=48).The preoperative and the postoperative 1-,3-,6-,and 12-month baseline data,visual analog scale(VAS)score,Roland-Morris Disability Questionnaire(RMDQ)score,Leeds Neurological Symptoms and Signs Score(LANSS),European Society for Quality of Life Five Dimensional Questionnaire(EQ-5D)score,and the use of non-steroidal anti-inflammatory and analgesic drugs were compared between the two groups.Results There was no statistically significant differences in the baseline data and the incidence of intraoperative and postoperative adverse reactions between the two groups(both P＞0.05).At 12 months after surgery,the VAS,RMDQ,LANSS,EQ-5D scores,and the use of non-steroidal anti-inflammatory and analgesic drugs in all patients were significantly better than those before surgery(all P＜0.05).The postoperative 3-,6-,and 12-month VAS,RMDQ,LANSS,EQ-5D scores,and the analgesic dosage in the study group were significantly better than those in the control group(all P＜0.05),and the percentages of patients with pain relief greater than 50％and greater than 80％were also significantly higher than those in the control group(all P＜0.01).Conclusion for the treatment of DBP,both CT-guided intradiscal injection of autologous PRP and CT-guided intradiscal injection of autologous PRP combined with PRF can significantly improve pain,body function,and quality of life in DBP patients,and significantly reduce the use of non-steroidal anti-inflammatory and analgesic drugs.The efficacy of autologous PRP combined with PRF is remarkably better than that of autologous PRP alone.
