The predicting value of tumor burden score in transcatheter arterial chemoembolization combined with microwave ablation for hepatocellular carcinoma
10.3969/j.issn.1008-794X.2025.08.012
- VernacularTitle:肿瘤负荷评分在TACE联合微波消融治疗肝细胞肝癌预后中的预测价值
- Author:
Mengjie YIN
1
;
Jiandong SHEN
Author Information
1. 226001 江苏南通 南通大学附属南通第三医院(南通市第三人民医院)介入血管科
- Keywords:
hepatocellular carcinoma;
transcatheter arterial chemoembolization;
microwave ablation;
tumor burden score;
prognosis
- From:
Journal of Interventional Radiology
2025;34(8):865-870
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the clinical value of tumor burden score(TBS)in predicting the prognosis of patients with early-to-middle hepatocellular carcinoma(HCC)after receiving transcatheter arterial chemoembolization(TACE)combined with microwave ablation(MWA).Methods The clinical data of 79 HCC patients,who received TACE combined with MWA at the Affiliated Nantong Third Hospital of Nantong University of China from January 2013 to December 2019,were retrospectively analyzed.Time-dependent ROC curve and area under the ROC curve(AUC)were used to evaluate the accuracy of TBS(TBS2=maximum tumor diameter2+number of tumor lesions2)in predicting 5-year survival and tumor-free survival.The optimal cut-off value of TBS was selected according to K-Means method,and the HCC patients were divided into three groups for survival analysis.Cox multivariate analysis screened out the independent factors affecting the prognosis of HCC patients after receiving TACE combined with MWA.Results ROC curve statistics showed that the AUC of TBS in predicting the 5-year survival rate of HCC patients after receiving TACE combined with MWA was 0.815,which was the best value,the AUC of maximum tumor diameter was 0.684,and the AUC of tumor number was 0.640.According to the optimal cut-off value,79 HCC patients were divided into three groups:TBS≤1.9 points(n=34,43.1％,group A),1.9＜TBS≤ 3.3 points(n=25,31.6％,group B),and TBS＞3.3 points(n=20,25.3％,group C).The survival analysis indicated that the 5-year overall survival rate in group A,group B and group C was 76.5％,56.7％and 6.3％respectively.With the increase of TBS value,the 5-year survival rate of patients decreased gradually.The differences in the 5-year survival rate between each other among the three groups were statistically significant(P＜0.05).The differences in the tumor-free survival rate between each other among the three groups were also statistically significant(P＜0.05),besides,with the increase of TBS value,the tumor-free survival rate decreased gradually.Multivariate analysis revealed that TBS was an independent factor affecting the overall survival rate and tumor-free survival rate in HCC patients after receiving TACE combined with MWA.Conclusion TBS can well predict the prognosis of HCC patients after receiving TACE combined with MWA.
