Transcatheter arterial chemoembolization combined with argon-helium cryoablation for the treatment of hypervascular small hepatocellular carcinoma:analysis of its clinical efficacy
10.3969/j.issn.1008-794X.2025.08.007
- VernacularTitle:经导管动脉化疗栓塞联合氩氦冷冻消融治疗富血供小肝细胞癌临床效果
- Author:
Dengwei ZONG
1
;
Yanli MEMG
;
Dongyang ZHANG
;
Jincheng XIAO
;
Jing LI
Author Information
1. 450008 河南郑州 郑州大学附属肿瘤医院(河南省肿瘤医院)微创介入科
- Keywords:
small hepatocellular carcinoma;
transcatheter arterial chemoembolization;
argon-helium cryoablation;
liver function;
immune function
- From:
Journal of Interventional Radiology
2025;34(8):840-846
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy of transcatheter arterial chemoembolization(TACE)combined with argon-helium cryoablation(AHC)in the treatment of hypervascular small hepatocellular carcinoma(sHCC).Methods The clinical data of 35 patients with hypervascular sHCC,who received TACE combined with AHC at the Affiliated Cancer Hospital of Zhengzhou University of China from March 2018 to February 2019,were retrospectively analyzed.All patients were treated with TACE treatment first,after 3-7 days the patients received AHC therapy.The postoperative 1-,3-,and 6-month curative effect were evaluated,and the postoperative 1-,3-,and 5-year survival rates were calculated.The liver function and immune function indicators,as well as the serum tumor markers were detected.The adverse reactions during treatment were recorded.Results The postoperative 1-,3-,and 6-month objective remission rate(ORR)were 100.00％,94.29％and 91.43％respectively,and the disease control rate(DCR)were 100.00％,100.00％and 97.14％ respectively.The overall survival(OS)was(46.54±2.88)months,and the postoperative 1-,3-,and 5-year survival rates were 94.29％(33/35),65.71％(23/35)and 48.57％(17/35)respectively.The postoperative 3-day serum levels of ALT,AST and TBIL were significantly elevated when compared with their preoperative baseline levels(all P＜0.05),which returned to preoperative levels in 2 weeks after treatment(P＞0.05).The postoperative 2-week CD4+％and CD4+％/CD8+％ratio were remarkably increased when compared with their preoperative values(both P＜0.05),while the postoperative 2-week AFP,AFP-L3％,DCP and GPC3 levels were strikingly decreased when compared with their preoperative values(all P＜0.001).None of the patients developed procedure-related severe complications after treatment.Conclusion For the treatment of hypervascular sHCC,TACE combined with AHC has satisfactory clinical efficacy and safety.
