The application of intravoxel incoherent motion diffusion-weighted imaging in evaluating the therapeutic effect of CalliSpheres drug-loaded microspheres for hepatocellular carcinoma
10.3969/j.issn.1008-794X.2025.04.012
- VernacularTitle:体素内不相干运动扩散加权成像技术对肝癌CalliSpheres载药微球治疗效果的评估
- Author:
Huimin LU
1
;
Qing YANG
;
Fei WANG
;
Zhi HU
;
Jiaying DAI
Author Information
1. 246003 安徽安庆 安庆市立医院医学影像科
- Keywords:
intravoxel incoherent motion;
CalliSpheres drug-loaded microspheres;
intervention of hepatocellular carcinoma;
efficacy evaluation
- From:
Journal of Interventional Radiology
2025;34(4):403-406
- CountryChina
- Language:Chinese
-
Abstract:
Objective By using intravoxel incoherent motion(IVIM)double exponential model liver multi-b value diffusion-weighted imaging(DWI)scanning technique to analyze the lesion's IVIM parameters before and after interventional treatment of hepatocellular carcinoma(HCC)with conventional transcatheter arterial chemoembolization(TACE)combined with CalliSpheres drug-loaded microspheres(DEB-TACE),based on which to quantitatively evaluate the efficacy of interventional therapy for HCC.Methods A total of 40 HCC patients,who were admitted to the Department of Interventional Therapy of Anqing Municipal Hospital of China from June 2022 to November 2023 to receive DEB-T ACE,were enrolled in this study.Routine MR examination,DWI and IVIM-DWI scan were performed before and at 1,3 and 6 months after treatment,and a total of 40 interest lesions were selected.The ADC value,perfusion fraction(f),pure diffusion coefficient(D),and perfusion-related diffusion coefficient(D*)of each lesion were analyzed.The receiver operating characteristic(ROC)curve was drawn to analyze the prognosis assessment value of IVIM-DWI parameters.Results After DEB-TACE treatment,the ADC value and D value were increased,and the f value was decreased when compared with their preoperative values,the differences were statistically significant(all P＜0.01).The ADC value and D value in the patients of effective group were remarkably higher than those in the patients of ineffective group,the differences were statistically significant(both P＜0.01);the f value in the patients of effective group was slightly lower than that in the patients of ineffective group,and the difference was statistically significant(P＜0.05).The areas under ROC curve of ADC value,D value and f value for evaluating efficacy were 0.762,0.877,and 0.708 respectively.The area under the curve for the joint assessment of the three parameters was 0.928,with the highest efficacy.Conclusion IVIM-DWI can quantitatively determine the microperfusion and activity of HCC lesions before and after interventional DEB-TACE treatment,and it can also evaluate the curative efficacy of interventional therapy for HCC as well as the outcome of HCC lesions.
