Research progress in hepatic arterial perfusion chemotherapy for advanced hepatocellular carcinoma complicated by portal vein tumor thrombus
10.3969/j.issn.1008-794X.2025.04.001
- VernacularTitle:肝动脉灌注化疗治疗晚期肝细胞癌合并门静脉癌栓的研究进展
- Author:
Zhengxin DUAN
1
;
Junchao WANG
;
Wei ZHAO
Author Information
1. 650032 云南昆明 昆明医科大学第一附属医院医学影像科
- Keywords:
hepatocellular carcinoma;
portal vein tumor thrombus;
hepatic arterial infusion chemotherapy
- From:
Journal of Interventional Radiology
2025;34(4):341-346
- CountryChina
- Language:Chinese
-
Abstract:
Pathologically,hepatocellular carcinoma(HCC)is prone to invade the portal vein and form portal vein tumor thrombus(PVTT).Although great advances in the treatment of HCC have been achieved in recent years,HCC patients with PVTT still have limited therapeutic options and poor prognosis.Hepatic arterial infusion chemotherapy(HAIC)is a therapeutic approach that combines local therapy with systemic antitumor effects,and a lot of studies have shown that HAIC carries certain survival benefit to patients with advanced HCC complicated by PVTT,and it is considered to be an effective local therapy for advanced HCC,especially for patients with type Vp3-4 HCC.Systemic therapy is the main treatment for advanced HCC,but the diversity of HAIC combined with targeted and immunotherapy may become a more effective treatment option for HCC with severe PVTT,and it is possible to achieve a tumor-free state through translational therapy,allowing patients with advanced HCC to survive for a longer time.This article aims to summarize the research progress in HAIC for advanced HCC complicated by PVTT.
