Research progress in the establishment of animal models with chronic limb-threatening ischemia
10.3969/j.issn.1008-794X.2025.03.002
- VernacularTitle:慢性肢体威胁性缺血动物模型研究进展
- Author:
Longshuang WANG
1
;
Donghua JI
Author Information
1. 116011 辽宁大连 大连医科大学附属第一医院介入治疗科
- Keywords:
lower limb artery;
chronic limb-threatening ischemia;
animal model
- From:
Journal of Interventional Radiology
2025;34(3):234-237
- CountryChina
- Language:Chinese
-
Abstract:
The animal models with chronic limb-threatening ischemia(CLTI)can be used to study the pathophysiological changes of CLTI so as to formulate more effective treatment strategies.In recent years,with the progress of clinical treatment techniques,studies on animal experimental models have been further improved and developed.Currently,the widely used animal models of CLTI include rodents(such as rats and mice)and large animals(such as rabbits and pigs).The methods of establishing CLTI animal model include ligation and excision,arterial electrocoagulation,Ameroid constrictor,and endovascular techniques.This review summarizes the recent major advances in the establishment of CLTI animal models,so as to enable the relevant workers to obtain a clearer understanding of the advantages and disadvantages of different animals and experimental methods,to improve the animal model,and to provide better treatment options for CLTI patients.
