The influence of balloon pulmonary angioplasty for chronic thromboembolic pulmonary hypertension on renal functions
10.3969/j.issn.1008-794X.2025.02.008
- VernacularTitle:球囊肺动脉成形术治疗慢性血栓栓塞性肺动脉高压对肾功能的作用
- Author:
Yuxuan FENG
1
;
Jinzhi WANG
;
Xincheng LI
;
Shuai ZHANG
;
Qian GAO
;
Tongsheng WANG
;
Yimin MAO
;
Wanmu XIE
;
Zhenguo ZHAI
;
Qiang HUANG
Author Information
1. 471000 河南洛阳 河南科技大学第一附属医院呼吸与危重症医学科
- Keywords:
chronic thromboembolic pulmonary hypertension;
balloon pulmonary angioplasty;
contrast-induced nephropathy;
renal function;
estimated glomerular filtration rate
- From:
Journal of Interventional Radiology
2025;34(2):160-165
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the incidence of contrast-induced nephropathy(CIN)in patients with chronic thromboembolic pulmonary hypertension(CTEPH)after receiving balloon pulmonary angioplasty(BPA),and to evaluate the effect of the contrast agents on renal function.Methods A total of 143 CTEPH patients,who received BPA at the China-Japan Friendship Hospital of China from December 2018 to May 2022,were enrolled in this study.The clinical data,hemodynamic indicators,and serum creatinine(SC)concentrations within one week before and 48-72 h after BPA were collected.The estimated glomerular filtration rate(eGFR)was calculated according to the Modification of Diet in Renal Disease(MDRD)formula.The SC concentration and eGFR changes before and after each BPA procedure were compared.The incidence of CIN and its risk factors were evaluated,and the changes in hemodynamics,SC and eGFR after the initial and last time of BPA treatment were analyzed.Results A total of 192 BPA procedures were performed in 115 CTEPH patients,including 88 BPA procedures in males and 103 BPA procedures in females.The mean amount of contrast agent used for each BPA was(145.58±47.26)mL.After BPA,12 patients developed 13 times of CIN,with an incidence of 6.8％.There was no significant differences(P＞0.05)in the baseline characteristics and SC concentration before BPA between CIN patients and non-CIN patients.In terms of the hemodynamic indexes,the mixed venous oxygen saturation(SvO2)in CIN patients was significantly lower than that in non-CIN patients(58.58％±10.38％vs.66.15％±8.02％,P=0.002),and no statistically significant differences(P＞0.05)in the other hemodynamic indexes existed between CIN group and non-CIN group.No statistically significant differences in SC concentration and eGFR existed before and after each BPA procedure.In patients who had received several BPA procedures,significant improvements in the SC[(78.09±18.760)μmol/L vs.(82.26±21.37)μmol/L,P＜0.001]and eGFR[(86.08±21.22)mL/(min·1.73 m2)vs.(82.07±22.05)mL/(min·1.73 m2),P=0.007]was achieved when compared with their baseline values.Conclusion CTEPH patients may develop CIN after receiving BPA treatment.After receiving several BPA treatments the patient's clinical symptoms and hemodynamics can be improved,and the patient's renal function is also significantly improved.
