Continuous radiofrequency versus high-voltage,long-duration pulsed radiofrequency of ganglia impar for the treatment of perineal pain in patients with rectal cancer:a clinical study
10.3969/j.issn.1008-794X.2025.02.007
- VernacularTitle:奇神经节持续射频与高电压长时程脉冲射频治疗直肠癌会阴痛临床研究
- Author:
Bo ZHONG
1
;
Taomei ZHANG
;
Zhiqiang WANG
;
Ping TAO
;
Huaiming WANG
;
Aimin ZHANG
Author Information
1. 641399 四川资阳 资阳市雁江区人民医院麻醉科
- Keywords:
ganglion impar;
radiofrequency thermocoagulation;
pulsed radiofrequency;
perineal pain;
cancerous pain;
DSA guidance
- From:
Journal of Interventional Radiology
2025;34(2):154-159
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy and safety of DSA-guided continuous radiofrequency ablation(CRF)and high-voltage,long-duration pulsed radiofrequency(HL-PRF)of ganglia impar in treating perineal pain in patients with rectal cancer.Methods This study is a single-center,randomized,active-controlled,double-blind trial that included 57 rectal cancer patients with perineal pain.At a 1∶1 ratio,the patients were randomly divided into CRF group(n=28)and HL-PRF group(n=29).The primary outcome indicators were the pain numerical rating scale(NRS)scores determined at the preoperative(T0),postoperative 24 h(T1),one week(T2),one month(T3),3 months(T4)and 6 months(T5)time-points.The secondary outcome indicators included the sitting time at T0,T1,T2,T3,T4 and T5 time-points,the 9-item patient health questionnaire(PHQ-9)score,the pittsburgh sleep quality index(PSQI)score,the postoperative oral morphine dosage,and the incidence of perineal numbness.Results Compared with the value at T0 time-point,in both groups the NRS score,PHQ-9 score and PSQI score at T1-T5 time-points were significantly decreased,while the sitting time become remarkably increased(all P＜0.05).No statistically significant differences in postoperative oral morphine dosage and incidence of perineal numbness existed between the two groups(both P＞0.05).There were no statistically significant differences in NRS score,PHQ-9 score and PSQI score,sitting time and oral morphine dosage at T1,T2,T3 time-points between CRF group and HL-PRF group(all P＞0.05),while at T4 and T5 time-points the NRS score,PHQ-9 score and PSQI score in HL-PRF group were significantly higher than those in CRF group(all P＜0.05),and the sitting time in HL-PRF group was strikingly lower than that in CRF group(P＜0.05).Conclusion Both CRF and HL-PRF of ganglion impar can alleviate perineal pain in patients with advanced rectal cancer and improve the quality of life of patients.CRF is superior to HL-PRF in the long-term efficacy.
