Clinical application of yttrium-90 microspheres in the treatment of hepatic metastases from colorectal cancer
10.3969/j.issn.1008-794X.2025.01.020
- VernacularTitle:钇90微球在结直肠癌肝转移治疗中的应用
- Author:
Xiaoyang ZHU
1
;
Guoliang SHAO
Author Information
1. 310053 浙江杭州 浙江中医药大学第二临床医学院
- Keywords:
yttrium-90;
microspheres;
colorectal cancer liver metastasis;
selective internal radiotherapy
- From:
Journal of Interventional Radiology
2025;34(1):115-120
- CountryChina
- Language:Chinese
-
Abstract:
The liver is the most common site of metastases from colorectal cancer,and its treatment is relatively difficult.Nowadays in China,selective internal radiotherapy(SIRT)with yttrium-90 microspheres for colorectal cancer liver metastasis(CRLM)has been employed in clinical practice.Although it has technical difficulties,this novel therapeutic mode of internal radiation therapy carries some unique advantages when compared with the traditional therapy.SIRT with yttrium-90 microspheres can effectively control the tumor progression and increase the volume of future liver remnant(FLR)for patients who are temporarily unable to receive surgical resection of the tumor,thus it can create conditions for subsequent R0 resection or radiation ablation.Combined with first-line and second-line chemotherapy,SIRT with yttrium-90 microspheres can improve the local regional response of liver metastases,thus providing patients with sufficient chemotherapy intervals.For patients whose chemotherapy failed and whose tumor is unresectable,SIRT with yttrium-90 microspheres can better control the tumor progression and prolong the survival of patients.SIRT with yttrium-90 microspheres combined with targeted therapy and immunotherapy also has broad application prospects.This paper aims to make a comprehensive review about the application and recent progress of yttrium-90 microspheres in treating CRLM.
