Analysis of cerebral amyloid angiopathy samples from Human Brain Bank of Hebei Medical University
10.16098/j.issn.0529-1356.2025.06.010
- VernacularTitle:河北医科大学人脑组织库脑淀粉样血管病样本分析
- Author:
Zu-Qi CUI
1
;
Meng-Yao YE
;
Yi ZHOU
;
Shi-Xiong MI
;
Qian YANG
;
Min MA
;
Ming WANG
;
Shi-Yi WANG
;
Qi-Han YU
;
Hui-Xian CUI
;
Juan DU
Author Information
1. 河北医科大学基础医学院
- Keywords:
Human Brain Bank;
Human brain sample;
Cerebral amyloid angiopathy;
Alzheimer's disease;
Comorbidity;
Neuropathological diagnosis;
Human
- From:
Acta Anatomica Sinica
2025;56(6):704-712
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the basic conditions and pathological characteristics of the samples in the Human Brain Bank of Hebei Medical University,which were pathologically diagnosed as cerebral amyloid angiopathy,and to provide reference for the research of related diseases.Methods The basic data of gender,age,apolipoprotein E genotype,pathological classification of cerebral amyloid angiopathy,Alzheimer's disease-related pathological change score,comorbidities and other pathological information were analyzed.Results Up to October 2024,twenty samples were confirmed by pathological diagnosis,with a male to female ratio of 3:1 and an average age of(80.90±8.08)years.Involve three kinds of apolipoprotein E subtype,5 kinds of genotypes(ε2/ε3 xε2/ε4、ε3/ε3 xε3/ε4、ε4/ε4);There were 2 pathologic types,including 6 cases of type 1 and 14 cases of type 2.The pathological grade included 3 grades.The severity grade and subtype classification of cerebral amyloid vascular disease were correlated with the degree of pathological changes of Alzheimer's disease.Cerebral amyloid angiopathy samples could coexist with other degenerative diseases with high comorbidity.Conclusion The incidence of cerebral amyloid angiopathy is higher in the aged samples collected based on Brain Bank,which coexists with conditions such as Alzheimer's disease and microbleeds,etc.It provides more detailed pathological diagnosis basis for further scientific research sharing of samples.
