Mechanism of di-(2-ethylhexyl)phthalate promoting the development of polycystic ovary syndrome
10.16098/j.issn.0529-1356.2025.05.016
- VernacularTitle:邻苯二甲酸二(2-乙基己基)酯促进多囊卵巢综合征发生发展的机制
- Author:
Liang CAI
1
;
An-Ni FENG
;
Yu-Hua CHEN
;
Yu-Bo XIAO
;
Zhong-Cheng MO
;
Yuan-Jie XIE
Author Information
1. 广西糖尿病系统医学重点实验室,桂林医科大学基础医学院组织学与胚胎学教研室,基础医学研究所,桂林 541199
- Keywords:
Polycystic ovary syndrome;
Di-(2-ethylhexyl)phthalate;
Insulin resistance;
Hypothalamic-pituitary-ovarian axis;
Epigenetic inheritance
- From:
Acta Anatomica Sinica
2025;56(5):625-633
- CountryChina
- Language:Chinese
-
Abstract:
Di-(2-ethylhexyl)phthalate(DEHP)is an environmental pollutant commonly found in plastic products and has toxic effects on female reproductive system.DEHP can interfere with the synthesis of progesterone,testosterone and estradiol through female hypothalamic-pituitary-ovarian axis,aggravate insulin resistance and obesity by affecting glucose and lipid metabolism,and cause ovarian damage through inducing oxidative stress,excessive autophagy and pyroptosis of oocyte or granulosa cells.It can also alter epigenetic genes relating to follicular development and prevent follicles from mature.These factors are closely contribute to the pathogenesis of polycystic ovary syndrome.We systematically summarizes the mechanism of DEHP interfering with ovarian function and inducing polycystic ovary syndrome,in order to provide help for the prevention and treatment of female reproductive injury from environmental pollutant.
