Genetic factors inducing abnormal lipid metabolism microglial cell formation in Alzheimer's disease
10.16098/j.issn.0529-1356.2025.04.015
- VernacularTitle:遗传因素诱导脂质积累小胶质细胞形成在阿尔茨海默病中的作用
- Author:
Hong-Yi SUN
1
;
Wei LIU
Author Information
1. 北京协和医学院护理学院,北京 100005
- Keywords:
Genetics;
Microglia;
Lipid metabolism;
Alzheimer's disease
- From:
Acta Anatomica Sinica
2025;56(4):493-498
- CountryChina
- Language:Chinese
-
Abstract:
Alzheimer's disease(AD)is one of the most common degenerative diseases of the central nervous system in the elderly population,and genetic factors play an important role in its development.Microglia,as resident macrophages in the central nervous system,are closely related to the occurrence and development of AD.Human AD brain tissue staining result and Genome-Wide Association Studies(GWAS)indicate that AD risk genes such as apolipoprotein E(APOE)4,triggering receptor expressed on myeloid cells 2(TREM2),REV-ERBα and ATP binding cassette(ABC)family are involved in inducing lipid metabolism disorders in microglia and the occurrence of lipid-droplet-accumulating microglia(LDAM).This article reviews the genetic causes of LDAM,and discusses the possible mechanism of AD induced by neuronal damage and other means.
