Effects of perioperative electroacupuncture on postoperative β-endorphin levels and pain in patients:a meta-analysis
10.16098/j.issn.0529-1356.2025.03.005
- VernacularTitle:围手术期电针对患者术后β-内啡肽水平及疼痛影响的Meta分析
- Author:
Ran HU
1
;
Zi-Chen LIU
;
Chang-Yi XU
;
Chen-Xing XIE
;
Chen WU
;
Yang CAO
;
Fan LIU
;
Li ZHANG
;
Guo-Kai LIU
Author Information
1. 北京中医药大学东直门医院,北京 100700
- Keywords:
Perioperative electroacupuncture;
Postoperative pain;
β-endorphin;
5-Hydroxytryptamine;
Prostaglandin E2;
Human
- From:
Acta Anatomica Sinica
2025;56(3):284-293
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the changes in postoperative plasma β-endorphin(β-EP)levels in patients who had received perioperative electroacupuncture(EA)treatment in 10 randomized controlled trials(RCTs)and examine the impact of EA on postoperative pain.Methods This meta-analysis evaluated the changes in plasma β-EP levels and visual analog scale(VAS)12,24 and 48 hours after surgery in patients receiving perioperative EA.It also assessed the changes in plasma serotonin(5-hydroxytryptamine,5-HT)and prostaglandin E2(PGE2)levels at 24 hours postsurgery.A comprehensive search was conducted in the China National Knowledge Infrastructure(CNKI),Wanfang,Chongqing VIP database,Chinese Biomedical Database(CBM),Web of Science,and PubMed databases.RCTs on perioperative EA and β-EP published from the inception of the websites up to July 25,2023,were retrieved.Effect size aggregation,literature quality assessment,and bias analysis were performed using RevMan 5.3 software,and sensitivity analysis was conducted via R 4.3.1.Results A total of 10 RCTs involving 706 patients were included.EA in conjunction with conventional anesthesia significantly increased plasma β-EP levels at 12 hours postsurgery[standard mean difference(SMD)=2.79,95%CI(1.85,3.72),Z=5.81,P＜0.00001],24hours postsurgery[SMD=1.87,95%CI(0.9,2.83),Z=3.79,P=0.0001],and 48 hours postsurgery[SMD=2.02,95%CI(1.49,2.54),Z=7.50,P＜0.00001].EA reduced plasma PGE2 levels at 24 hours postsurgery and plasma 5-HT levels at 24 hours postsurgery,and the VAS at 12,24 and 48 hours after surgery also decreased.Conclusion These findings suggest that perioperative EA markedly elevates plasma β-EP levels,reduces pain-inducing factors in plasma,and effectively alleviates acute postoperative pain.
