Research progress Review on the role and regulatory mechanism of fructose-1,6-bisphosphatase 1 in tumors occurrence and development
10.16098/j.issn.0529-1356.2025.02.016
- VernacularTitle:果糖-1,6-二磷酸酶1在肿瘤发生发展中的作用及调控机制的研究进展
- Author:
Bo-Wen SUN
1
;
Yuan CHENG
Author Information
1. 北京大学人民医院妇产科,北京 100044
- Keywords:
Fructose-1,6-bisphosphatase 1;
Tumor;
Metabolism;
Progression
- From:
Acta Anatomica Sinica
2025;56(2):248-251
- CountryChina
- Language:Chinese
-
Abstract:
The metabolic enzyme fructose-1,6-bisphosphatase 1(FBP1)plays an important role in tumour development.In a variety of tumors,the high expression level of FBP1 has been correlated with a good prognosis.FBP1 can regulate the tumor cell metabolism reprograming by inhibiting glycolysis and fat metabolism,play the roles of protein phosphatase by regulating the NF-κB pathway and block tumor progression by regulating tumour immune cell infiltration.However,FBP1 promote malignant progression in a few tumors,some of the regulatory mechanisms are still unclear and need to be followed up with further research.
