Research progress of downstream signal pathway of Piezo1 in cell mechanics microenvironment
10.16098/j.issn.0529-1356.2025.01.016
- VernacularTitle:细胞力学微环境中Piezo1下游信号通路的研究进展
- Author:
Zhuo-Yuan HAN
1
;
Hui PENG
;
Xiao-Yue ZHAI
;
Yuan-Yuan FU
Author Information
1. 中国医科大学第一临床学院,沈阳 110801
- Keywords:
Piezo1;
Mechanical force;
Extracellular matrix
- From:
Acta Anatomica Sinica
2025;56(1):120-126
- CountryChina
- Language:Chinese
-
Abstract:
There are a variety of mechanical signals in the microenvironment of cells,which have temporal and spatial variability,which jointly regulate the histological processes such as cell proliferation,differentiation and migration.Piezo1 is a mechanically sensitive cationic channel.As a force sensor,it transmits signals to downstream pathways and participates in a variety of life activities in response to changes in the cell microenvironment.In this paper,the common signal pathways of Piezo1 were reviewed in order to identify the downstream signaling pathways regulated by Piezo1,thereby providing theoretical basis for inhibiting or delaying related diseases.
