Morphology of enteric nervous system in C57BL/6 mice based on fMOST high-resolution 3D reconstruction system
10.16098/j.issn.0529-1356.2025.01.015
- VernacularTitle:基于fMOST高分辨率3D重建系统的C57BL/6小鼠模型内脏神经系统的形态学观察
- Author:
Li-Ge LENG
1
;
Guan-Xiong YANG
;
Ze-En WANG
;
Yi CHEN
;
Zhi-Liang QIAO
;
Qing-Zhong HU
;
Ming-Yan WANG
;
Feng TIAN
Author Information
1. 厦门大学医学院解剖学教研室,厦门 361102
- Keywords:
Enteric nervous system;
Mucosal layer;
Auerbach plexus;
Meissner plexus;
Fluorescence micro-optical sectioning tomography;
Mouse
- From:
Acta Anatomica Sinica
2025;56(1):114-119
- CountryChina
- Language:Chinese
-
Abstract:
Objective To initially explore the possibility of applying the fluorescence micro-optical sectioning tomography(fMOST)high-resolution 3D reconstruction system to the morphological study of the intestinal nervous system and to preliminarily establish a method for studying the morphology of the intestinal nervous system using this system.Methods fMOST high-resolution 3D reconstruction system was used to study the intestinal nervous system of C57BL/6 mice in detail.Based on this method,a new morphological method of the visceral nervous system of small animal models was explored at the single-cell level.Results Compared with the large intestine,the small intestine lacked the typical myenteric plexus(Auerbach),deep mucosal plexus(Henley),and submucosal superficial plexus(Meissner).Conclusion The result of this paper provide a clearer and systematic display of the anatomical structure of the enteric nervous system in C57BL/6 mice,and further clarify the similarities and differences between the enteric nervous system of mice and human,and provide a theoretical basis for its rational application in the study of digestive system diseases.The morphological study of fMOST high-resolution 3D reconstruction system is not limited to the central nervous system,but can be extended to the morphological study of multiple visceral nervous systems.
