Association of digit ratio with polymorphisms at three loci of matrix metalloproteinase 9 gene in Ningxia Han youths
10.16098/j.issn.0529-1356.2025.01.010
- VernacularTitle:宁夏汉族青年指长比与基质金属蛋白酶9基因3个位点多态性的关联性
- Author:
Meng-Yi YANG
1
;
Jin ZHANG
;
Shi-Bo NIU
;
Jie DANG
;
Zhan-Bing MA
;
Hong LU
;
Zheng-Hao HUO
;
Yu XU
;
Dan SHEN
Author Information
1. 宁夏医科大学基础医学院;生育力保持教育部省部共建重点实验室,银川 750004
- Keywords:
Matrix metallopeptidase 9;
Genetic polymorphism;
Digit ratio;
Anatomical measurement;
Multiplex PCR;
Ningxia Han youth
- From:
Acta Anatomica Sinica
2025;56(1):74-79
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association of digit ratio with single nucleotide polymorphism(SNP)at three loci(rs17576,rs3918249,rs9509)of matrix metallopeptidase 9(MMP-9)gene.Methods A total of 804 Ningxia Han youths(399 males and 405 females)were used as the study subjects.A digital camera was used to take frontal photographs of the hands,and image analysis software was used to mark the anatomical points and measure the lengths of each finger of both hands(2D,3D,4D,5D);Multiplexed PCR was used to detect the three polymorphic sites of the MMP-9 gene,SPSS 25.0 and R Studio software were used for data analysis and plotting.Results The 2D/3D(P＜0.05)and 2D/4D(left,P＜0.01,right,P＜0.05)of both hands,2D/5D(P＜0.01),3D/5D,4D/5D(P＜0.05)of the right hand,and 3D/4D(P＜0.05)of the left hand in female youths of Ningxia Han were significantly higher than those in males,Differences in genotypes and allele frequencies at all 3 loci of the MMP-9 gene were not statistically significant between genders(P＞0.05).Right hand 2D/4D was significantly associated with genotypes at the rs17576 and rs3918249 loci in male youths(P＜0.05).Conclusion MMP-9 gene SNPs(rs17576 and rs3918249)may be associated with the formation of 2D/4D of Ningxia Han male youths.
