Post-translational modification of integrins and its relationship with tumor occurrence and development
10.16098/j.issn.0529-1356.2025.01.008
- VernacularTitle:整合素翻译后修饰及其与肿瘤发生发展的关系
- Author:
Jia YANG
1
;
Xiao WU
;
Jin-Suo BO
;
Yi-Ning CHEN
;
Hong-Quan ZHANG
;
Xiao-Fan WEI
Author Information
1. 北京大学基础医学院人体解剖学与组织胚胎学系,北京 100083
- Keywords:
Integrin;
Post-translational modification;
Tumor progression;
Cell migration
- From:
Acta Anatomica Sinica
2025;56(1):58-65
- CountryChina
- Language:Chinese
-
Abstract:
Integrins are transmembrane receptors that can coordinate signal transduction between cells and extracellular matrix or between cells.The abnormal function of integrins is one of the recognized mechanisms of tumor development.As an important regulatory mode,post-translational modification can change the conformation and physicochemical properties of proteins,thus affecting their activities,stability and functions.After the modification of the integrin,such as glycosylation and methylation,the corresponding signal transduction pathway changes,and then affects cell adhesion,migration,differentiation and other life activities,involving in diverse physiology and pathological processes.Post-translational modifications of integrins are abundant in tumor progression and play a key role in regulating the growth,metastasis and drug resistance of different tumor cells.In this review,the structure and function,post-translational modification of integrins,and their relationship with occurrence and development of tumors will be discussed,in order to provide more explorable targets for the treatment of cancer.
