Role of homeobox B9 and its post-translational modifications in the genesis and development of tumor
10.16098/j.issn.0529-1356.2025.01.007
- VernacularTitle:同源盒蛋白B9及其翻译后修饰在肿瘤发生发展中的作用
- Author:
Jun-Ming HE
1
;
Miao YU
;
Hong-Quan ZHANG
;
Jun ZHAN
Author Information
1. 北京大学医学部,北京 100083;北京大学医学部人体解剖学与组织学胚胎学系,癌症发生与转化研究教育部重点实验室,北京大学国际癌症研究院,北京 100083
- Keywords:
Homeobox B9;
Post-translational modifications;
Tumor
- From:
Acta Anatomica Sinica
2025;56(1):50-57
- CountryChina
- Language:Chinese
-
Abstract:
Homeobox(HOX)genes encode a group of proteins that are highly conserved and closely related to the axial differentiation of embryos.The disorder of segmental development caused by HOX genes deficiency or abnormal expression has been observed in drosophila and mice.However,subsequent studies have found that proteins encoded by the HOX gene family are also involved in the regulation of tumor genesis and development.The roles of the whole HOX family had been reviewed by the author in the past,and through the in-depth researches,the author paid attention to the pivotal role of HOXB9 and made new progress in the study of post-translational modifications of this protein.Taking HOXB9 as a clue,this review summarizes the tumor-related signaling pathways and the modulating effects of post-translational modification of HOXB9 on tumor progression,as well as the possible research directions in the future.
